|
KMID : 0380519970010010007
|
|
Korean Journal of Veterinary Pathology
1997 Volume.1 No. 1 p.7 ~ p.12
|
|
|
Regeneration of Immune System after Syngeneic Bone Marrow Transplantation in Irradiated Mice: II. B Lymphocyte Regeneration and Antibody Production
|
|
Kim Seong-Ho
Oh Heon
Lee Song-Eun
Kim Soon-Tae
Jo Sung-Kee
Hyun Byung-Hwa
Ryu Si-Yun
Daynes Raymond A.
|
|
|
Abstract
|
|
|
|
Lethally irradited C3H/HeN mice were transplanted with syngeneic bone marrow. The B cell regeneration levels of spontaneous serum Ig, fecal igA and specific ig to diphtheria toxoid were determined at various time points. The number of B220+ cells reached normal range at 4 weeks after bone marrow transplantation(BMT) in spleen and lymph node. The B cell number of spleen returned to normal relatively soon than in the lymph node. Within 5 to 7 weeks after BMT, the transplanted mice contained nearly normal levels of spontaneous serum IgA, IgG2b and fecal IgA, but 2 fold lower levels of serum IgG2a, IgM and IgG3. Especially IgG3 levels were within low-normal range throughout the study. One to two weeks after immunization the predominant anti-diphtheria toxoid subtype was IgM. The levels of specific serum Ig were very low and after booster immunization at week 6, the short-lasting increase of Ig production was notd.
|
|
|
KEYWORD
|
|
|
Ig production, mouse, regeneration of B cell, syngeneic bone marrow transplantation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|